OBJECTIVES/GOALS: Antibodies play an important role in the pathogenesis of a wide range of diseases, including cancer, autoimmune diseases, and infections.There are currently no reliable methods to isolate and study specific plasma cell subpopulations as antibody production sources.We aim to develop methods to study plasma cells in high resolution.

A primary feature of drug addiction is the compulsive use despite negative consequences.A general consensus is emerging on the capacity of addictive substances to co-opt synaptic transmission and synaptic plasticity in brain circuits which are involved in reinforcement and reward processing.A current hypothesis is that drug-driven neuroadaptations

Animals are believed to be homeostatic by maintaining relatively constant body nutrient content independently of changes in diet.Phosphorus (P) is one of the most important elements for fishes as Loricariids, which are covered with armor-like bony plates.These species are expected to maintain nutrient homeostasis, however, in environments with low

Introduction Since the beginning of the pandemic in 2020, COVID-19 has changed the medical landscape.International recommendations for localized prostate cancer (PCa) include deferred treatment and adjusted therapeutic routines.Materials and methods To longitudinally evaluate changes in PCa treatment strategies in urological and radiotherapy depart